The Houston Chronicle is the largest daily newspaper in Houston, Texas, United States. As of April 2016, it is the third-largest newspaper by Sunday circulation in the United States, behind only The New York Times and the Los Angeles Times. With its 1995 buy-out of long-time rival the Houston Post, the Chronicle became Houston's newspaper of record.

The Houston Chronicle is the largest daily paper owned and operated by the Hearst Corporation, a privately held multinational corporate media conglomerate with $10 billion in revenues. The paper employs nearly 2,000 people, including approximately 300 journalists, editors, and photographers. The Chronicle has bureaus in Washington, D.C. and Austin. It reports that its web site averages 125 million page views per month.

It has two websites: chron.com and houstonchronicle.com.