Key points from article :
Calorie restriction isn't a way to achieve meaningful rejuvenation in humans.
It produces a much greater impact on life span in short-lived mammals than in long-lived mammals.
Sex-specific functional states of microglia analyzed in vivo in mice.
Done in young adults, middle aged, and old wild type mice.
This is by means of multicolor two-photon imaging, using the microglial Ca2+ signaling.
Data revealed sex-specific differences in microglial Ca2+ signaling at all ages tested.
For both sexes, functional state of microglia changes at least twice in a lifespan.
6-12 months long caloric restriction counteracted these aging-induced change.
Shifting many but not all functional properties of microglia toward a younger phenotype.
Even short-term (6-week-long) caloric restriction beginning at old age had benefits.
It strongly improved microglial process motility, induced improved microglial Ca2+ signaling.
Researchers from Eberhard Karls University Tübingen, published in Frontiers in Immunology.
/calorie-restriction-cr-thumbnail.jpg)
